GLIOTOXIN, GLADIOCLADIUM FIMBRIATUM
Gliotoxin
CAS: 67-99-2
Molecular Formula: C13H14N2O4S2
GLIOTOXIN, GLADIOCLADIUM FIMBRIATUM - Names and Identifiers
GLIOTOXIN, GLADIOCLADIUM FIMBRIATUM - Physico-chemical Properties
| Molecular Formula | C13H14N2O4S2 |
| Molar Mass | 326.39 |
| Density | 1.4069 (rough estimate) |
| Melting Point | 221°C (rough estimate) |
| Boling Point | 699.7±55.0 °C(Predicted) |
| Specific Rotation(α) | D25 -290° (c = 0.08 in ethanol) |
| Flash Point | 2℃ |
| Solubility | DMSO: 10 mg/mL;ethanol: 2 mg/mL. |
| Appearance | Powder |
| Color | Monoclinic crystals from MeOH |
| Merck | 13,4454 |
| BRN | 50675 |
| pKa | 12.90±0.40(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 2 yeara as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| Refractive Index | 1.6510 (estimate) |
| MDL | MFCD00058534 |
GLIOTOXIN, GLADIOCLADIUM FIMBRIATUM - Risk and Safety
| Risk Codes | R25 - Toxic if swallowed R36 - Irritating to the eyes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. |
| UN IDs | UN 3462 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | KB4725000 |
| FLUKA BRAND F CODES | 4.2-10-23 |
| HS Code | 29419090 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 oral in mouse: 67mg/kg |
GLIOTOXIN, GLADIOCLADIUM FIMBRIATUM - Reference Information
| Introduction | as one of the mycotoxins produced by Aspergillus fumigatus, it has immunosuppressive and pro-apoptotic effects on mammalian cells. It inhibits the antimicrobial effect of granulocytes by inhibiting the activity of NAPDH oxidase. |
| biological activity | Gliotoxin is A secondary metabolite. fumigatus secretes the most abundant mycotoxins, inhibiting the phagocytosis of macrophages and the immune function of other immune cells. Gliotoxin inhibits inducible NF-κB activity by preventing degradation of IκB, thereby inducing host cell apoptosis. Gliotoxin can activate PKA and increase intracellular cAMP concentration; Regulate actin cytoskeletal rearrangement to promote internalization of A. fumigatus into lung epithelial cells. |
| category | pesticide |
| toxicity grade | high toxicity |
| Acute toxicity | oral-mouse LD50: 67 mg/kg; Intraperitoneal-mouse LDL0: 45 mg/kg |
| flammability hazard characteristics | flammable; Toxic sulfur oxide and nitrogen oxide gases from combustion |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored and transported separately from food raw materials |
| extinguishing agent | dry powder, foam, sand |
Last Update：2024-04-09 19:05:16
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